General Information

    • DRAMP ID

    • DRAMP00205

    • Peptide Name

    • Tricyclic peptide RP 71955 (Bacteriocin)

    • Source

    • Streptomyces sp. (strain SP9440) (Gram-positive bacteria)

    • Family

    • Belongs to the class 1 lasso peptide

    • Gene

    • Not found

    • Sequence

    • CLGIGSCNDFAGCGYAVVCFW

    • Sequence Length

    • 21

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • Virus: HIV-1

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Cyclization of a N-terminal between Cys1 and Asp9

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys1 and Cys 13,Cys 7 and Cys19.

    • Stereochemistry

    • L

    • Structure

    • Beta strand

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00205 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP00205.

Physicochemical Information

    • Formula

    • C97H137N23O27S4

    • Absent Amino Acids

    • EHKMPQRT

    • Common Amino Acids

    • CG

    • Mass

    • 2185.53

    • PI

    • 3.8

    • Basic Residues

    • 0

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • -1

    • Boman Index

    • 19.81

    • Hydrophobicity

    • 1.157

    • Aliphatic Index

    • 74.29

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 7240

    • Absorbance 280nm

    • 362

    • Polar Residues

    • 11

DRAMP00205

DRAMP00205 chydropathy plot

Comments Information

    • Function

    • Active against HIV-1 virus in vitro.

Literature Information

  • ·Literature 1

    • Title

    • Isolation of RP 71955, a new anti-HIV-1 peptide secondary metabolite.

    • Reference

    • J Antibiot (Tokyo). 1993 Nov;46(11):1756-1757.

    • Author

    • Helynck G, Dubertret C, Mayaux JF, Leboul J.
  • ·Literature 2

    • Title

    • Solution structure of RP 71955, a new 21 amino acid tricyclic peptide active against HIV-1 virus.

    • Reference

    • Biochemistry. 1994 Jan 11;33(1):42-50.

    • Author

    • Fréchet D, Guitton JD, Herman F, Faucher D, Helynck G, Monegier du Sorbier B, Ridoux JP, James-Surcouf E, Vuilhorgne M.