General Information

    • DRAMP ID

    • DRAMP00245

    • Peptide Name

    • Gramicidin A (GA; Nonribosomally synthesized bacteriocin)

    • Source

    • Bacillus brevis (soil bacterium) (Gram-positive bacteria)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VGALAVVVWLWLWLW

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antbacterial, Antiviral

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Beta strand (1 strands; 13 residues)

    • Structure Description

    • Amino acids 4, 6, 8, 10, and 12 are D-amino acids, allowing the formation of a special helical structure that head-to-head dimerizes into a cation channel in lipid bilayer with the C-terminus exposed. Structures solved in organic solvents by x-ray diffraction are believed to be non-channel forms.

    • Helical Wheel Diagram

    • DRAMP00245 helical wheel diagram

    • PDB ID

    • 1MAG resolved by NMR.

    • Predicted Structure

    • There is no predicted structure for DRAMP00245.

Physicochemical Information

    • Formula

    • C96H135N19O16

    • Absent Amino Acids

    • CDEFHIKMNPQRSTY

    • Common Amino Acids

    • LVW

    • Mass

    • 1811.25

    • PI

    • 5.49

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 14

    • Net Charge

    • 0

    • Boman Index

    • 49.72

    • Hydrophobicity

    • 2.107

    • Aliphatic Index

    • 194.67

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 22000

    • Absorbance 280nm

    • 1571.43

    • Polar Residues

    • 1

DRAMP00245

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : I. PREPARATION OF THE AGENT. ITS ACTIVITY IN VIT.

    • Reference

    • J Exp Med. 1939 Jun 30;70(1):1-10.

    • Author

    • Dubos RJ.
  • ·Literature 2

    • Title

    • Macromolecular structural elucidation with solid-state NMR-derived orientational constraints.

    • Reference

    • J Biomol NMR. 1996 Jul;8(1):1-14.

    • Author

    • Ketchem RR, Lee KC, Huo S, Cross TA.