• DRAMP ID

    • DRAMP00834
    • Peptide Name

    • Cycloviolacin-Y2 (Plants)
    • Source

    • Viola yedoensis (Chinese herb)
    • Family

    • Belongs to the cyclotide family
    • Gene

    • Not found
    • Sequence

    • GGTIFDCGESCFLGTCYTAGCSCGNWGLCYGTN
    • Sequence Length

    • 33
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antiviral
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • No specific N-terminal
    • C-terminal Modification

    • No specific C-terminal
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys7 and Cys21; Cys11 and Cys23; Cys16 and Cys29.
    • Stereochemistry

    • L
    • Structure

    • Bridge
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP00834 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP00834.
    • Formula

    • C141H202N36O48S6
    • Absent Amino Acids

    • HKMPQRV
    • Common Amino Acids

    • G
    • Mass

    • 3361.73
    • PI

    • 3.67
    • Basic Residues

    • 0
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 7
    • Net Charge

    • -2
    • Boman Index

    • -6.11
    • Hydrophobicity

    • 0.285
    • Aliphatic Index

    • 38.48
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 8855
    • Absorbance 280nm

    • 276.72
    • Polar Residues

    • 24

DRAMP00834

DRAMP00834 chydropathy plot
    • Function

    • Has anti-HIV activity. PTM
  • ·Literature 1
    • Title

    • Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.
    • Reference

    • J Nat Prod. 2008 Jan;71(1):47-52.
    • Author

    • Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ.