General Information

    • DRAMP ID

    • DRAMP00835

    • Peptide Name

    • Cycloviolacin-Y3 (Plants)

    • Source

    • Viola yedoensis (Chinese herb)

    • Family

    • Belongs to the cyclotide family

    • Gene

    • Not found

    • Sequence

    • GGTIFDCGETCFLGTCYTAGCSCGNWGLCYGTN

    • Sequence Length

    • 33

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • No specific N-terminal

    • C-terminal Modification

    • No specific C-terminal

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys7 and Cys21; Cys11 and Cys23; Cys16 and Cys29.

    • Stereochemistry

    • L

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00835 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00835.

Physicochemical Information

    • Formula

    • C142H204N36O48S6

    • Absent Amino Acids

    • HKMPQRV

    • Common Amino Acids

    • G

    • Mass

    • 3375.75

    • PI

    • 3.67

    • Basic Residues

    • 0

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 7

    • Net Charge

    • -2

    • Boman Index

    • -5.28

    • Hydrophobicity

    • 0.288

    • Aliphatic Index

    • 38.48

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 8855

    • Absorbance 280nm

    • 276.72

    • Polar Residues

    • 24

DRAMP00835

DRAMP00835 chydropathy plot

Comments Information

    • Function

    • Has anti-HIV activity. PTM

Literature Information

  • ·Literature 1

    • Title

    • Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.

    • Reference

    • J Nat Prod. 2008 Jan;71(1):47-52.

    • Author

    • Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ.