• DRAMP ID

    • DRAMP00931
    • Peptide Name

    • Antimicrobial peptide 3 (Cn-AMP3; Plant defensin)
    • Source

    • Cocos nucifera (Coconut palm)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • TCSYTMEA
    • Sequence Length

    • 8
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.19111587] Gram-positive bacteria: Bacillus subtilis (MIC=257 μg/ml) and Staphylococcus aureus (MIC=274 μg/ml);
      • Gram-negative bacteria: Escherichia coli (MIC=302 μg/ml) and Pseudomonas aeruginosa (MIC=259 μg/ml).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Free
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP00931 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP00931.
    • Formula

    • C36H56N8O15S2
    • Absent Amino Acids

    • DFGHIKLNPQRVW
    • Common Amino Acids

    • T
    • Mass

    • 905.01
    • PI

    • 4
    • Basic Residues

    • 0
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 1
    • Net Charge

    • -1
    • Boman Index

    • -10.05
    • Hydrophobicity

    • -0.1
    • Aliphatic Index

    • 12.5
    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1490
    • Absorbance 280nm

    • 212.86
    • Polar Residues

    • 5

DRAMP00931

    • Function

    • Antibacterial activity against Gram-negative and Gram-positive bacteria.
    • Tissue specificity

    • Found in the liquid endosperm contained in green fruit of coconut palms, also known as coconut water (at protein level).
    • Subunit structure

    • Monomer.
  • ·Literature 1
    • Title

    • Identification and structural insights of three novel antimicrobial peptides isolated from green coconut water.
    • Reference

    • Peptides. 2009 Apr;30(4):633-637.
    • Author

    • Mandal SM, Dey S, Mandal M, Sarkar S, Maria-Neto S, Franco OL.