General Information
-
DRAMP ID
- DRAMP00939
-
Peptide Name
- Type-5 thionin (Type V thionin; Plant defensin)
-
Source
- Triticum aestivum (Wheat)
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Family
- Belongs to the thionin family
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Gene
- TTHV
-
Sequence
- VDCGANPFKVACFNSCLLGPSTVFQCADFCACRLPAG
-
Sequence Length
- 37
-
UniProt Entry
- Q05806
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Cytotoxic
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00939.
Physicochemical Information
-
Formula
- C166H254N44O48S6
Absent Amino Acids
- EHIMWY
Common Amino Acids
- C
Mass
- 3826.47
PI
- 5.9
Basic Residues
- 2
Acidic Residues
- 2
Hydrophobic Residues
- 15
Net Charge
- 0
-
Boman Index
- -7.75
Hydrophobicity
- 0.676
Aliphatic Index
- 68.65
Half Life
-
- Mammalian:100 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 375
Absorbance 280nm
- 10.42
Polar Residues
- 14
DRAMP00939
Comments Information
Function
- Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane.
PTM
- Contains three disulfide bonds 3-40; 12-30; 16-26.
Literature Information
- ·Literature 1
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Title
- Extreme divergence of a novel wheat thionin generated by a mutational burst specifically affecting the mature protein domain of the precursor.
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Pubmed ID
- 1569564
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Reference
- J Mol Biol. 1992 Apr 20;224(4):1003-1009.
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Author
- Castagnaro A, Mara±a C, Carbonero P, Garca-Olmedo F.