• DRAMP ID

    • DRAMP01248
    • Peptide Name

    • Dybowskin-1 (Frogs, amphibians, animals)
    • Source

    • Rana dybowskii (Korea brown frog)
    • Family

    • N/A
    • Gene

    • N/A
    • Sequence

    • FLIGMTHGLICLISRKC
    • Sequence Length

    • 17
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • N/A
    • Biological Activity

    • Antibacterial, Anti-Gram+, Antimicrobial
    • Target Organism

      • [Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=12.5 µg/ml), Staphylococcus aureus KCTC3881 (MIC=25 µg/ml), Bacillus subtilis ATCC6633 (MIC=50 µg/ml), Staphylococcus epidermidis ATCC 12228 (MIC=60 µg/ml).
    • Hemolytic Activity

      • [Ref:17698251]0.99% hemolytic activity at 100 μg/ml against huamn red blood cells
    • Cytotoxicity

    • Binding Target

    • N/A
    • Linear/Cyclic/Branched

    • N-terminal modification

    • C-terminal modification

    • Other modifications

    • Stereochemistry

    • Structure

    • N/A
    • Structure Description

    • N/A
    • DRAMP01248 helical wheel diagram
    • Formula

    • C85H145N23O20S3
    • Absent Amino Acids

    • ADENPQVWY
    • Common Amino Acids

    • IL
    • Mass

    • 2191
    • PI

    • 8.83
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 7
    • Boman Index

    • 8.19
    • Hydrophobicity

    • 121.76
    • Aliphatic Index

    • 137.65
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 7.81
    • Polar Residues

    • 6

DRAMP01248

    • Function

    • Dybowskin-1 has low hemolytic activity against human red blood cells (hRBCs).
  • Literature 1
    • Reference

    • Peptides 2007; 28: 1532-1539.
    • Author

    • Kim SS, Shim MS, Chung J, Lim DY, Lee BJ.
    • Title

    • Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii.