General Information

    • DRAMP ID

    • DRAMP01293

    • Peptide Name

    • Phylloseptin-5 (PS-5; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa oreades (Orange-legged leaf frog) (Monkey frog)

    • Family

    • Not found

    • Gene

    • psn5

    • Sequence

    • FLSLIPHAINAVSAIAKHS

    • Sequence Length

    • 19

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antiprotozoal

    • Target Organism

    • Trypanosoma cruzi (IC50=4.9 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01293 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01293.

Physicochemical Information

    • Formula

    • C92H149N25O24

    • Absent Amino Acids

    • CDEGMQRTWY

    • Common Amino Acids

    • A

    • Mass

    • 1989.35

    • PI

    • 8.76

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • 7.15

    • Hydrophobicity

    • 0.921

    • Aliphatic Index

    • 138.95

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01293

DRAMP01293 chydropathy plot

Comments Information

    • Function

    • Has antiprotozoal activity against Trypanosoma cruzi.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.

    • Reference

    • Peptides. 2005 Apr;26(4):565-573.

    • Author

    • Leite JR, Silva LP, Rodrigues MI, Prates MV, Brand GD, Lacava BM, Azevedo RB, Bocca AL, Albuquerque S, Bloch C Jr.