• DRAMP ID

    • DRAMP01319
    • Peptide Name

    • Cathelicidin-AL (Gly-rich; Frogs, amphibians, animals)
    • Source

    • Amolops loloensis
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • RRSRRGRGGGRRGGSGGRGGRGGGGRSGAGSSIAGVGSRGGGGGRHYA
    • Sequence Length

    • 48
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=6.25 µg/ml), Staphylococcus aureus ATCC43300 (MIC=6.25 µg/ml), Bacillus subtilis (MIC=100 µg/ml);
      • Gram-negative bacteria: Escherichia coli ML-35P (MIC=25 µg/ml), Psecdomonas aeruginosa PA01 (MIC=12.5 µg/ml), Psecdomonas aeruginosa ATCC27853 (MIC=6.25 µg/ml).
      • Yeast: Candida albicans ATCC2002 (MIC=50 µg/ml).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • [Ref.22009138]No cytotoxic against HUVEC or RMMCs at the concentration of 0.4 mg/ml.
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Free
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01319 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01319.
    • Formula

    • C171H296N86O56
    • Absent Amino Acids

    • CDEFKLMNPQTW
    • Common Amino Acids

    • G
    • Mass

    • 4452.77
    • PI

    • 12.7
    • Basic Residues

    • 13
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 5
    • Net Charge

    • +13
    • Boman Index

    • -168.23
    • Hydrophobicity

    • -1.217
    • Aliphatic Index

    • 20.42
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 1490
    • Absorbance 280nm

    • 31.7
    • Polar Residues

    • 30

DRAMP01319

DRAMP01319 chydropathy plot
    • Function

    • Has antibacterial against Gram-positive and Gram-negative bacteria. Also has antifungal activity against C. albicans.
  • ·Literature 1
    • Title

    • Amphibian cathelicidin fills the evolutionary gap of cathelicidin in vertebrate.
    • Reference

    • Amino Acids. 2012 Aug;43(2):677-685.
    • Author

    • Hao X, Yang H, Wei L, Yang S, Zhu W, Ma D, Yu H, Lai R.