• DRAMP ID

    • DRAMP01368
    • Peptide Name

    • Maculatin-2.1 (Frogs, amphibians, animals)
    • Source

    • Litoria genimaculata (brown-spotted treefrog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GFVDFLKKVAGTIANVVT
    • Sequence Length

    • 18
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • Gram-positive bacteria: Bacillus cereus (MIC=100 µg/ml), Micrococcus luteus (MIC=100 µg/ml), Staphylococcus aureus (MIC=100 µg/ml), Staphylococcus epidermidis (MIC=50 µg/ml), Streptococcus uberis (MIC=25 µg/ml). (Ref.2)
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01368 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01368.
    • Formula

    • C88H143N21O24
    • Absent Amino Acids

    • CEHMPQRSWY
    • Common Amino Acids

    • V
    • Mass

    • 1879.23
    • PI

    • 8.59
    • Basic Residues

    • 2
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 10
    • Net Charge

    • +1
    • Boman Index

    • 5.86
    • Hydrophobicity

    • 0.961
    • Aliphatic Index

    • 118.89
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 5

DRAMP01368

DRAMP01368 chydropathy plot
    • Function

    • Shows antibacterial activity against the Gram-positive bacteria.
    • Tissue specificity

    • Expressed by the skin dorsal glands.
    • PTM

    • C-terminal amidation.
  • ·Literature 1
    • Title

    • The maculatin peptides from the skin glands of the tree frog Litoria genimaculata: a comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1.
    • Reference

    • J Pept Sci. 1998 Apr;4(2):111-115.
    • Author

    • Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.
  • ·Literature 2
    • Title

    • Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.
    • Reference

    • Peptides. 2004; 25: 1035-1054.
    • Author

    • Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.