• DRAMP ID

    • DRAMP01452
    • Peptide Name

    • Esculentin-1LTa (Frogs, amphibians, animals)
    • Source

    • Hylarana latouchii (Broad-folded frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • RISFKKGKGSWIKNGLIKGIKGLGKEISLDVIRTGIDIAGCKIKGEC
    • Sequence Length

    • 47
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=0.6 µM), Bacillus licheniformis X39 (MIC=10 µM), Staphylococcus carnosus KHS (MIC=1.3 µM), Rhodococcus rhodochrous X15 (MIC=0.3 µM);
      • Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=5 µM), Serratia rubidaea X01 (MIC=10 µM), Psychrobacter faecalis X29 (MIC=0.6 µM).
      • Yeast: Candida albicans ATCC2002 (MIC=80 µM).
    • Hemolytic Activity

      • [Ref.22426384] LD50>480 μM against human erythrocytes
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys41 and Cys47)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys41 and Cys47.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01452 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01452.
    • Formula

    • C225H388N64O61S2
    • Absent Amino Acids

    • HMPQY
    • Common Amino Acids

    • GIK
    • Mass

    • 5030.07
    • PI

    • 9.94
    • Basic Residues

    • 11
    • Acidic Residues

    • 4
    • Hydrophobic Residues

    • 16
    • Net Charge

    • +7
    • Boman Index

    • -49.04
    • Hydrophobicity

    • -0.075
    • Aliphatic Index

    • 107.87
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 5625
    • Absorbance 280nm

    • 122.28
    • Polar Residues

    • 16

DRAMP01452

DRAMP01452 chydropathy plot
    • Comment

    • No comments found on DRAMP database
  • ·Literature 1
    • Title

    • Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii.
    • Reference

    • Biochimie. 2012 Jun;94(6):1317-1326.
    • Author

    • Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J.