• DRAMP ID

    • DRAMP01589
    • Peptide Name

    • Citropin-1.1 sm2 (Frogs, amphibians, animals)
    • Source

    • Synthesized modify
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GLFDVIAKVASVIGGL
    • Sequence Length

    • 16
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • Gram-positive bacteria: Bacillus cereus (MIC=100 µg/ml), Leuconostoc lactis (MIC=25 µg/ml), Micrococcus luteus (MIC=100 µg/ml), Staphylococcus aureus (MIC=100 µg/ml), Staphylococcus epidermidis (MIC=100 µg/ml), Streptococcus uberis (MIC=100 µg/ml).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01589 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01589.
    • Formula

    • C73H123N17O20
    • Absent Amino Acids

    • CEHMNPQRTWY
    • Common Amino Acids

    • GV
    • Mass

    • 1558.88
    • PI

    • 5.84
    • Basic Residues

    • 1
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 10
    • Net Charge

    • 0
    • Boman Index

    • 23.55
    • Hydrophobicity

    • 1.638
    • Aliphatic Index

    • 164.38
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 4

DRAMP01589

    • Function

    • Amphibian defensive peptide.
    • Tissue specificity

    • Expressed by the dorsal and submental skin glands.
  • ·Literature 1
    • Title

    • Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1.
    • Reference

    • Eur J Biochem. 1999 Oct;265(2):627-637.
    • Author

    • Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ.