General Information

    • DRAMP ID

    • DRAMP01590

    • Peptide Name

    • Citropin 1.1 M14 (Frogs, amphibians, animals)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLFDVIAKVASVIKKL

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: E. coli (MIC=53 µM);
      • Gram-positive bacterium: S. aureus (MIC=3 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01590 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01590.

Physicochemical Information

    • Formula

    • C81H141N19O20

    • Absent Amino Acids

    • CEHMNPQRTWY

    • Common Amino Acids

    • KV

    • Mass

    • 1701.13

    • PI

    • 9.7

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +2

    • Boman Index

    • 10.57

    • Hydrophobicity

    • 1.2

    • Aliphatic Index

    • 164.38

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP01590

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin, and maculatin.

    • Reference

    • Biopolymers. 2011;96(2):147-157.

    • Author

    • Chia CS, Gong Y, Bowie JH, Zuegg J, Cooper MA.