• DRAMP ID

    • DRAMP02257
    • Peptide Name

    • Ranatuerin-2P (Ranatuerin 2P; Frogs, amphibians, animals)
    • Source

    • Rana luteiventris (Spotted frog) (Rana pretiosa)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Unknow
    • Sequence

    • LMDTVKNVAKNLAGHMLDKLKCKITGC
    • Sequence Length

    • 27
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antiviral
    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=13 µM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC=50 µM).
      • Yeast: Candida albicans (MIC=67 µM).
    • Binding Traget

    • Unknow
    • Structure

    • Unknow
    • Structure Description

    • Unknow
    • PDB ID

    • Unknow
    • DRAMP02257 helical wheel diagram
    • Formula

    • C126H222N36O36S4
    • Absent Amino Acids

    • EFPQRSWY
    • Common Amino Acids

    • K
    • Mass

    • 3409.59
    • PI

    • 9.55
    • Basic Residues

    • 6
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 9
    • Boman Index

    • -22.83
    • Hydrophobicity

    • 5.93
    • Aliphatic Index

    • 101.11
    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 4.81
    • Polar Residues

    • 8
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Amino Acid Distribution

DRAMP02257 chydropathy plot
    • Function

    • This peptide could inhibit HIV infection at a concentration that is also toxic to T cells (J Virol 2005; 79
  • Literature 1
    • Reference

    • Eur J Biochem. 2000 Feb;267(3):894-900.
    • Author

    • Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.
    • Title

    • Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.