General Information

    • DRAMP ID

    • DRAMP02397

    • Peptide Name

    • Big defensin (RPD-1)

    • Source

    • Venerupis philippinarum (Japanese carpet shell) (Tapes japonica)

    • Family

    • Belongs to the big defensin family

    • Gene

    • Not found

    • Sequence

    • AVPDVAFNAYG

    • Sequence Length

    • 11

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=9.6 mg/L), Bacillus subtilis (MIC=76.8 mg/L), Micrococcus tetragenus (MIC=38.4 mg/L);
      • Gram-negative bacteria: Escherichia coli (MIC=76.8 mg/L), Vibrio parahaemolyticus (MIC=19.2 mg/L), Vibrio anguillarum (MIC=19.2 mg/L).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02397 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02397.

Physicochemical Information

    • Formula

    • C52H74N12O16

    • Absent Amino Acids

    • CEHIKLMQRSTW

    • Common Amino Acids

    • A

    • Mass

    • 1123.23

    • PI

    • 3.8

    • Basic Residues

    • 0

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • -1

    • Boman Index

    • 1.93

    • Hydrophobicity

    • 0.573

    • Aliphatic Index

    • 80

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 149

    • Polar Residues

    • 3

DRAMP02397

Comments Information

    • Function

    • Significantly inhibits the growth of Gram-negative and Gram-positive bacteria and fungi in vitro. Has antibacterial activity.

Literature Information

  • ·Literature 1

    • Title

    • Purification of a big defensin from Ruditapes philippinesis and its antibacterial activity.

    • Reference

    • Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Dec;35(12):1145-8.

    • Author

    • Wei YX, Guo DS, Li RG, Chen HW, Chen PX.