• DRAMP ID

    • DRAMP02455
    • Peptide Name

    • L-amino-acid oxidase (ACL-LAO; LAAO; LAO)
    • Source

    • Agkistrodon contortrix laticinctus (Broad-banded copperhead)(Agkistrodon mokasen laticinctus)
    • Family

    • Belongs to the flavin monoamine oxidase family (FIG1 subfamily)
    • Gene

    • Unknown
    • Sequence

    • ADSRNPLEEEFRETNYEEF
    • Sequence Length

    • 19
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antiparasitic, Antimicrobial
    • Target Organism

      • No MICs found on DRAMP database
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP02455 helical wheel diagram
    • Formula

    • C102H147N27O39
    • Absent Amino Acids

    • CGHIKMQVW
    • Common Amino Acids

    • E
    • Mass

    • 2696.66
    • PI

    • 3.79
    • Basic Residues

    • 2
    • Acidic Residues

    • 7
    • Hydrophobic Residues

    • 4
    • Boman Index

    • -86.12
    • Hydrophobicity

    • -177.37
    • Aliphatic Index

    • 25.79
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1490
    • Absorbance 280nm

    • 82.78
    • Polar Residues

    • 5

DRAMP02455

DRAMP02455 chydropathy plot
    • Function

    • Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids (L-Ile followed by L-Phe, L-Met, L-Val, L-Arg, L-Leu), thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage (minimum hemorrhagic dose of 10 µg), and apoptosis. May also induce hemolysis, edema, antibacterial and antiparasitic activities. May also regulate platelet aggregation. Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions.
    • Tissue specificity

    • Expressed by the venom gland.
  • Literature 1
    • Reference

    • Arch Biochem Biophys. 1999 Aug 15;368(2):285-290.
    • Author

    • Souza DH, Eugenio LM, Fletcher JE, Jiang MS, Garratt RC, Oliva G, Selistre-de-Araujo HS.
    • Title

    • Isolation and structural characterization of a cytotoxic L-amino acid oxidase from Agkistrodon contortrix laticinctus snake venom: preliminary crystallographic data.