General Information
-
DRAMP ID
- DRAMP03224
-
Peptide Name
- M-ctenitoxin-Cs1c (M-CNTX-Cs1c; Cupiennin-1c; spiders, Arthropods, animals)
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Source
- Cupiennius salei (Wandering spider)
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Family
- Belongs to the cupiennin family
-
Gene
- Not found
-
Sequence
- GFGSLFKFLAKKVAKTVAKQAAKQGAKYIANKQTE
-
Sequence Length
- 35
-
UniProt Entry
- P83621
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-negative bacteria: Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853;
- Gram-positive bacteria: Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03224.
Physicochemical Information
-
Formula
- C174H285N47O46
Absent Amino Acids
- CDHMPRW
Common Amino Acids
- K
Mass
- 3771.46
PI
- 10.3
Basic Residues
- 8
Acidic Residues
- 1
Hydrophobic Residues
- 15
Net Charge
- +7
-
Boman Index
- -35.88
Hydrophobicity
- -0.34
Aliphatic Index
- 70
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1490
Absorbance 280nm
- 43.82
Polar Residues
- 8
DRAMP03224
Comments Information
Function
- Has antimicrobial activity. Probably acts by disturbing membrane Function
Literature Information
- ·Literature 1
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Title
- Cupiennin 1, a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae).
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Pubmed ID
- 11792701
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Reference
- J Biol Chem. 2002 Mar 29;277(13):11208-11216.
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Author
- Kuhn-Nentwig L, Muller J, Schaller J, Walz A, Dathe M, Nentwig W.