General Information

    • DRAMP ID

    • DRAMP03573

    • Peptide Name

    • LL-37(13-37)(C-terminal fragment of LL-37; Human, mammals, animals)

    • Source

    • Homo sapiens (Human)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • IGKEFKRIVQRIKDFLRNLVPRTES

    • Sequence Length

    • 25

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Anticancer

    • Target Organism

      • Gram-negative bacterium: Escherichia coli K12 (MIC=80 µM).
      • Drug-resistant KBv cancer cells (LC50=39 µM), Drug-sensitive KB cancer cells (LC50=40 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds

    • Stereochemistry

    • L

    • Structure

    • Alpha helix (1 helices; 14 residues)

    • Structure Description

    • Residues 17-29 of LL-37(13-37) are helical.

    • Helical Wheel Diagram

    • DRAMP03573 helical wheel diagram

    • PDB ID

    • 2FCG resolved by NMR.

    • Predicted Structure

    • There is no predicted structure for DRAMP03573.

Physicochemical Information

    • Formula

    • C137H232N42O36

    • Absent Amino Acids

    • ACHMWY

    • Common Amino Acids

    • R

    • Mass

    • 3043.61

    • PI

    • 10.93

    • Basic Residues

    • 7

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +4

    • Boman Index

    • -77.24

    • Hydrophobicity

    • -0.624

    • Aliphatic Index

    • 101.2

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP03573

DRAMP03573 chydropathy plot

Comments Information

    • The slightly lower activity of LL-37(13-37) may result from the interference of the disordered regions with membrane binding of the peptide.

Literature Information

  • ·Literature 1

    • Title

    • Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region.

    • Reference

    • J Am Chem Soc. 2006 May 3;128(17):5776-5785.

    • Author

    • Li X, Li Y, Han H, Miller DW, Wang G.