General Information

    • DRAMP ID

    • DRAMP03574

    • Peptide Name

    • LL-37(17-32)(C-terminal fragment of LL-37; Human, mammals, animals)

    • Source

    • Homo sapiens (Human)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FKRIVQRIKDFLRNLV

    • Sequence Length

    • 16

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Anticancer

    • Target Organism

      • Gram-negative bacteria: Escherichia coli K12(MIC=20 µM).
      • Drug-resistant KBv cancer cells (LC50=30 µM), Drug-sensitive KB cancer cells (LC50=30 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • To achieve selective membrane targeting, D-amino acids were incorporated into LL-37(17-32). The D-peptide showed similar antibacterial activity to the L-diastereomer, it lost toxicity to human cells.

    • Helical Wheel Diagram

    • DRAMP03574 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03574.

Physicochemical Information

    • Formula

    • C95H161N29O21

    • Absent Amino Acids

    • ACEGHMPSTWY

    • Common Amino Acids

    • R

    • Mass

    • 2045.51

    • PI

    • 11.72

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +4

    • Boman Index

    • -43.04

    • Hydrophobicity

    • -0.075

    • Aliphatic Index

    • 133.75

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP03574

Comments Information

    • Antibacterial and anticancer assays found that LL-37(17-32) was more active than LL-37(13-37).

Literature Information

  • ·Literature 1

    • Title

    • Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region.

    • Reference

    • J Am Chem Soc. 2006 May 3;128(17):5776-5785.

    • Author

    • Li X, Li Y, Han H, Miller DW, Wang G.