Sequence Information

    • DRAMP ID

    • DRAMP18061

    • Name

    • Histatin

    • Sequence

    • DXHEKRHHGYRRKFHEKHHSHREFPFYGDYGSNYLYDN

    • Description

    • using a variant of histatins, which are naturally occurring cationic peptides in saliva

    • Activity

    • Antifungal(fungal cell membrane,mitochondrion)

    • Target Organism

      • Histatins manifest an in vivo IC50 value of approximately 1.4 μM

    • Reference

      • Histatins: antimicrobial peptides with therapeutic potential. J. Pharm. Pharmacol. (2004).(PMID: 15025852)
      • Safety and clinical effects of topical histatin gels in human with experimental gingivitis. J Clin Periodontol (2002)(PMID: 12492903)

Clinical Information

    • Medical use

    • antimicrobial-peptide-containing mouth wash for the treatment of oral candidiasis (gingivitis and periodontal diseases)

    • Company

    • Demgen and Dow Pharmaceutical Sciences;licensed to the Vancouver, Canada, company Pacgen

    • Stage of Development

    • Phase II-III

    • Comments

    • In a randomised double-blind clinical trial in 106 subjects, histatin derivatives were found to be more effective than placebo in preventing experimental gingivitis

    • Clinical Trials