Sequence Information

    • DRAMP ID

    • DRAMP18062

    • Name

    • Ramoplanin(NTI-851)

    • Sequence

    • NNXXTXXXFXXXXGLAX

    • Description

    • Ramoplanin(NTI-851) is a macrocyclic glycolipodepsipeptideproduced by Actinoplanesspp. being developed by Nano-therapeutics.It exhibits bactericidal activity by blocking the cell wall peptidoglycansynthesis of gram-positive bacteria. Recently, the phase III clinicalstudy of the peptide was initiated for the oral treatment ofvancomycin-resistantenterococcus(VRE) colonization, as well as the phase II trial against Clostridium difficile.

    • Activity

    • Antibacterial

    • Target Organism

      • No MICs found on DRAMP database

    • Reference

      • Deciphering the mode of action of cell wall-inhibiting antibiotics using metabolic labeling of growing peptidoglycan in Streptococcus pyogenes.(PMID: 28442740)

Clinical Information

    • Medical use

    • Treatment of bacterial infections.

    • Company

    • Nano-therapeutics

    • Stage of Development

    • Phase III

    • Comments

    • No more comments

    • Clinical Trials

    • Not listed