General Information

    • DRAMP ID

    • DRAMP18210

    • Peptide Name

    • Amythiamicin C/D(Bacteriocin)

    • Source

    • Amycolatopsis sp. (strain MI481-42F4 / FERM P-12739)

    • Family

    • Belongs to the class I bacteriocin

    • Gene

    • Not found

    • Sequence

    • SCNCVCGVCCSC

    • Sequence Length

    • 12

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antiparasitic

    • Target Organism

    • Gram-positive

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Elongation Factor Tu (EF-Tu)

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • The main frame from C-1 to C-41 of these antibiotics was the same as that of amythiamicin D. Amino acid autoanalyses of amythiamicins A, B and C showed that these have another one mole of serine and proline in comparison with amythiamicin D. Stereochemistries of both amino acids were determined to be L by chiral HPLC. These seryl-prolyl residues in amythiamicins A, B and C are attached at C-41 through an oxazoline ring, amide and ester

    • Helical Wheel Diagram

    • DRAMP18210 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18210.

Physicochemical Information

    • Formula

    • C40H69N13O16S6

    • Absent Amino Acids

    • ADEFHIKLMPQRTWY

    • Common Amino Acids

    • C

    • Mass

    • 1180.43

    • PI

    • 5.23

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • 0

    • Boman Index

    • 326

    • Hydrophobicity

    • 1.492

    • Aliphatic Index

    • 48.33

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 34.09

    • Polar Residues

    • 10

DRAMP18210

Comments Information

    • Sequence uncertainty (position 4)

    • C or T. Function

Literature Information

  • ·Literature 1

    • Title

    • Novel antibiotics, amythiamicins. I. Taxonomy, fermentation, isolation, physico-chemical properties, and antimicrobial activity.

    • Reference

    • J Antibiot (Tokyo). 1994 Jun;47(6):668-74.

    • Author

    • Shimanaka K, Kinoshita N, Iinuma H, Hamada M, Takeuchi T.
  • ·Literature 2

    • Title

    • Novel antibiotics, amythiamicins. III. Structure elucidations of amythiamicins A, B and C.

    • Reference

    • J Antibiot (Tokyo). 1994 Oct;47(10):1153-9.

    • Author

    • Shimanaka K, Takahashi Y, Iinuma H, Naganawa H, Takeuchi T.
  • ·Literature 3

    • Title

    • Total synthesis of the thiopeptide antibiotic amythiamicin D.

    • Reference

    • J Am Chem Soc. 2005 Nov 9;127(44):15644-51.

    • Author

    • Hughes RA, Thompson SP, Alcaraz L, Moody CJ.