General Information

    • DRAMP ID

    • DRAMP18449

    • Peptide Name

    • Kunitzin-OS (amphibians, animals)

    • Source

    • Chinese frog, Odorrana schmackeri

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AVNIPFKVHLRCKAAFC

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antibacterial, Enzyme inhibitor, Anti-Gram-, Antimicrobial

    • Target Organism

      • Gram-negative bacteria: E. coli (MIC 20 uM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18449 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18449.

Physicochemical Information

    • Formula

    • C88H141N25O19S2

    • Absent Amino Acids

    • DEGMQSTWY

    • Common Amino Acids

    • A

    • Mass

    • 1917.36

    • PI

    • 9.51

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +4

    • Boman Index

    • -545

    • Hydrophobicity

    • 0.712

    • Aliphatic Index

    • 97.65

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 7.81

    • Polar Residues

    • 3

DRAMP18449

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Kunitzins: Prototypes of a new class of protease inhibitor from the skin secretions of European and Asian frogs

    • Reference

    • Biochem Biophys Res Commun. 2016 Aug 19;477(2):302-9.

    • Author

    • Chen X, Wang H, Shen Y, Wang L, Zhou M, Chen T, Shaw C.