• DRAMP ID

    • DRAMP18450
    • Peptide Name

    • Kunitzin-RE (amphibians, animals)
    • Source

    • European frog, Rana esculenta
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • AAKIILNPKFRCKAAFC
    • Sequence Length

    • 17
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Biological Activity

    • Antibacterial, Enzyme inhibitor, Anti-Gram-, Antimicrobial
    • Target Organism

      • Gram-negative bacteria: E. coli (MIC 30 uM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP18450 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP18450.
    • Formula

    • C87H144N24O19S2
    • Absent Amino Acids

    • DEGHMQSTVWY
    • Common Amino Acids

    • A
    • Mass

    • 1894.37
    • PI

    • 9.85
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +4
    • Boman Index

    • -769
    • Hydrophobicity

    • 0.547
    • Aliphatic Index

    • 92.35
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 7.81
    • Polar Residues

    • 3

DRAMP18450

    • Fuction

    • A change of the last K to F reduced activity (MIC 160 uM).
  • ·Literature 1
    • Title

    • Kunitzins: Prototypes of a new class of protease inhibitor from the skin secretions of European and Asian frogs
    • Reference

    • Biochem Biophys Res Commun. 2016 Aug 19;477(2):302-9.
    • Author

    • Chen X, Wang H, Shen Y, Wang L, Zhou M, Chen T, Shaw C.