General Information
-
DRAMP ID
- DRAMP18450
-
Peptide Name
- Kunitzin-RE (amphibians, animals)
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Source
- European frog, Rana esculenta
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- AAKIILNPKFRCKAAFC
-
Sequence Length
- 17
-
UniProt Entry
- No entry found
-
Protein Existence
Activity Information
-
Biological Activity
- Antibacterial, Enzyme inhibitor, Anti-Gram-, Antimicrobial
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Target Organism
-
- Gram-negative bacteria: E. coli (MIC 30 uM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18450.
Physicochemical Information
-
Formula
- C87H144N24O19S2
Absent Amino Acids
- DEGHMQSTVWY
Common Amino Acids
- A
Mass
- 1894.37
PI
- 9.85
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 9
Net Charge
- +4
-
Boman Index
- -769
Hydrophobicity
- 0.547
Aliphatic Index
- 92.35
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 7.81
Polar Residues
- 3
DRAMP18450
Comments Information
Fuction
- A change of the last K to F reduced activity (MIC 160 uM).
Literature Information
- ·Literature 1
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Title
- Kunitzins: Prototypes of a new class of protease inhibitor from the skin secretions of European and Asian frogs
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Pubmed ID
- 27311856
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Reference
- Biochem Biophys Res Commun. 2016 Aug 19;477(2):302-9.
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Author
- Chen X, Wang H, Shen Y, Wang L, Zhou M, Chen T, Shaw C.