General Information
-
DRAMP ID
- DRAMP18452
-
Peptide Name
- CZS-2 (cruzioseptin-2; frog, amphibians, animals)
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Source
- the splendid leaf frog, Cruziohyla calcarifer, South America
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GFLDVIKHVGKAALGVVTHLINQ
-
Sequence Length
- 23
-
UniProt Entry
- No entry found
-
Protein Existence
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal
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Target Organism
- Active against E. coli (26.3 uM), S. aureus (6.6 uM), and C. albicans (13.2 uM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18452.
Physicochemical Information
-
Formula
- C112H183N31O28
Absent Amino Acids
- CEMPRSWY
Common Amino Acids
- V
Mass
- 2429.89
PI
- 8.61
Basic Residues
- 4
Acidic Residues
- 1
Hydrophobic Residues
- 12
Net Charge
- +3
-
Boman Index
- 629
Hydrophobicity
- 0.708
Aliphatic Index
- 137.92
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 5
DRAMP18452
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer.
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Pubmed ID
- 27321580
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Reference
- J Proteomics. 2016 Sep 2;146:1-13.
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Author
- Proa?o-Bola?os C, Zhou M, Wang L, Coloma LA, Chen T, Shaw C.