General Information

    • DRAMP ID

    • DRAMP18453

    • Peptide Name

    • CZS-1 (cruzioseptin-1; frog, amphibians, animals)

    • Source

    • the splendid leaf frog, Cruziohyla calcarifer, South America

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GFLDIVKGVGKVALGAVSKLF

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • Active against E. coli (15.1 uM), S. aureus (3.8 uM), and C. albicans (3.8 uM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18453 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18453.

Physicochemical Information

    • Formula

    • C101H168N24O25

    • Absent Amino Acids

    • CEHMNPQRTWY

    • Common Amino Acids

    • GV

    • Mass

    • 2118.59

    • PI

    • 9.7

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +2

    • Boman Index

    • 2041

    • Hydrophobicity

    • 1.157

    • Aliphatic Index

    • 139.05

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP18453

DRAMP18453 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer.

    • Reference

    • J Proteomics. 2016 Sep 2;146:1-13.

    • Author

    • Proa?o-Bola?os C, Zhou M, Wang L, Coloma LA, Chen T, Shaw C.