General Information

    • DRAMP ID

    • DRAMP18454

    • Peptide Name

    • Tepmporin-1Ee (frog, amphibians, animals)

    • Source

    • skin secretion, the European edible frog, Pelophylax kl. esculentus, Europe.

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLPVIAGVLSKLF

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.27255993]Gram-positive bacteria: S. aureus (MIC= 10 μM);
      • Gram-negative bacteria: E. coli (MIC= 40 μM)

    • Hemolytic Activity

      • [Ref.27255993]Non-hemolytic activity at 10 μM

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18454 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18454.

Physicochemical Information

    • Formula

    • C71H114N14O15

    • Absent Amino Acids

    • CDEHMNQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 1403.77

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +1

    • Boman Index

    • 2752

    • Hydrophobicity

    • 1.923

    • Aliphatic Index

    • 172.31

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP18454

Comments Information

    • Fuction

    • It showed no hemolytic activity at 10 μM.

Literature Information

  • ·Literature 1

    • Title

    • Identification and bioactivity evaluation of two novel temporins from the skin secretion of the European edible frog, Pelophylax kl. esculentus.

    • Reference

    • Biochem Biophys Res Commun. 2016 Aug 5;476(4):566-73.

    • Author

    • Chen X, Wang H, Yang M, Wang L, Zhou M, Chen T, Shaw C.