General Information
-
DRAMP ID
- DRAMP18456
-
Peptide Name
- Pepcon (peptide consensus sequence, synthetic)
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Source
- Designed based on sequence alignment with scorpion linear peptides
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Family
- Not found
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Gene
- Not found
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Sequence
- FSLIPSAIGGLISA
-
Sequence Length
- 18
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UniProt Entry
- No entry found
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Protein Existence
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-positive bacteria: S. epidermidis ATCC 12228 (MIC 7.5 uM),S. aureus (5 uM);
- Gram-negative bacteria: E. coli ATCC 25922 (MIC 50 uM), S. enterica ATCC 10708 (60 uM), P. aeruginosa ATCC 27853 (40uM), A. baumannii ATCC 19606 (MIC 20 uM),K. pneumoniae (60 uM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18456.
Physicochemical Information
-
Formula
- C63H104N14O18
Absent Amino Acids
- CDEHKMNQRTVWY
Common Amino Acids
- IS
Mass
- 1345.6
PI
- 5.52
Basic Residues
- 0
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- 0
-
Boman Index
- 2288
Hydrophobicity
- 1.621
Aliphatic Index
- 153.57
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 5
DRAMP18456
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Peptide consensus sequence determination for the enhancement of the antimicrobial activity and selectivity of antimicrobial peptides.
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Pubmed ID
- 28096686
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Reference
- Infect Drug Resist. 2016 Dec 29;10:1-17.
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Author
- Almaaytah A, Ajingi Y, Abualhaijaa A, Tarazi S, Alshar'i N, Al-Balas Q