General Information

    • DRAMP ID

    • DRAMP18458

    • Peptide Name

    • Melimine (a hybrid peptide of melittin and protamine, synthetic)

    • Source

    • Synthetic

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • TLISWIKNKRKQRPRVSRRRRRRGGRRRR

    • Sequence Length

    • 29

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18458 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18458.

Physicochemical Information

    • Formula

    • C158H288N74O34

    • Absent Amino Acids

    • ACDEFHMY

    • Common Amino Acids

    • R

    • Mass

    • 3786.52

    • PI

    • 13.08

    • Basic Residues

    • 16

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +16

    • Boman Index

    • -20915

    • Hydrophobicity

    • -2.193

    • Aliphatic Index

    • 48.67

    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 189.66

    • Polar Residues

    • 6

DRAMP18458

DRAMP18458 chydropathy plot

Comments Information

    • This peptide, consisting of the C-terminal regions of melittin and protamine, has been covalently immobilized 2008 via the N-terminus. Melimine coated contact lens reduced bacterial colonization (S. aureus and P. aeruginosa) by~70%.

Literature Information

  • ·Literature 1

    • Title

    • A novel cationic-peptide coating for the prevention of microbial colonization on contact lenses.

    • Reference

    • J Appl Microbiol. 2008 Dec;105(6):1817-25.

    • Author

    • Willcox MD, Hume EB, Aliwarga Y, Kumar N, Cole N.