General Information

    • DRAMP ID

    • DRAMP18459

    • Peptide Name

    • hLF(1-11) (hLF1-11, first 11 residues, human lactoferrin; synthetic)

    • Source

    • Synthetic fragment

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GRRRRSVQWCA

    • Sequence Length

    • 11

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Active against S. aureus, L. monocytogenes, E. coli, and K. pneumoniae.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18459 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP18459.

Physicochemical Information

    • Formula

    • C56H93N25O13S

    • Absent Amino Acids

    • DEFHIKLMNPTY

    • Common Amino Acids

    • R

    • Mass

    • 1374.59

    • PI

    • 12

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +4

    • Boman Index

    • -5822

    • Hydrophobicity

    • -1.258

    • Aliphatic Index

    • 32.5

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 500

    • Polar Residues

    • 3

DRAMP18459

Comments Information

    • Fuction

    • hLF(1

Literature Information

  • ·Literature 1

    • Title

    • Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria.

    • Reference

    • Infect Immun. 2001 Mar;69(3):1469-76.

    • Author

    • Nibbering PH, Ravensbergen E, Welling MM, van Berkel LA, van Berkel PH, Pauwels EK, Nuijens JH.
  • ·Literature 2

    • Title

    • Covalent immobilization of hLf1-11 peptide on a titanium surface reduces bacterial adhesion and biofilm formation.

    • Reference

    • Acta Biomater. 2014 Aug;10(8):3522-34.

    • Author

    • Godoy-Gallardo M, Mas-Moruno C, Fern