• DRAMP ID

    • DRAMP18502
    • Peptide Name

    • TSG-10 (Ixosin-B peptide derivative)
    • Source

    • Synthetic construct
    • Family

    • Derived from Ixosin-B
    • Gene

    • Not found
    • Sequence

    • WKSYVRRWR
    • Sequence Length

    • 9
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.23570790]Gram-positive bacteria: Staphylococcus aureus (MIC=64 μM);
      • Gram-negative bacteria: Escherichia coli (MIC=64 μM), Pseudomonas aeruginosa (MIC>100 μM)
    • Hemolytic Activity

      • [Ref.23570790]1.1±1.3% hemolysis at 100μM against human red blood cells.
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP18502 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP18502.
    • Formula

    • C63H93N21O12
    • Absent Amino Acids

    • ACDEFGHILMNPQT
    • Common Amino Acids

    • R
    • Mass

    • 1336.57
    • PI

    • 11.72
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 3
    • Net Charge

    • +4
    • Boman Index

    • -4515
    • Hydrophobicity

    • -1.9
    • Aliphatic Index

    • 32.22
    • Half Life

      • Mammalian:2.8 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 12490
    • Absorbance 280nm

    • 1561.25
    • Polar Residues

    • 2

DRAMP18502

    • Function

    • Antibacterial activity against Gram-positive and Gram-negative bacteria. Weak hemolytic activity.
  • ·Literature 1
    • Title

    • Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide.
    • Reference

    • Bioorg Med Chem Lett. 2013 May 15;23(10):2929-32.
    • Author

    • Wu YS, Liao ZJ, Wang KS, Lung FD.