General Information

    • DRAMP ID

    • DRAMP18506

    • Peptide Name

    • OG2 (Palustrin-OG1 peptide derivative)

    • Source

    • Synthetic construct (Modified Palustrin-OG1)

    • Family

    • Derived from Palustrin-OG1

    • Gene

    • Not found

    • Sequence

    • KKFFLKVLTKIRCKVAGGCRT

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.22670762]Gram-positive bacteria: Bacillus subtilis 1A751 (MIC=128 μg/mL), Staphylococcus aureus ATCC25923 (MIC=8 μg/mL);
      • Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=8 μg/mL),Salmonella choleraesuis CMCC50020 (MIC=16 μg/mL)

    • Hemolytic Activity

      • [Ref.22670762]7%±2% hemolysis at 2-256 μg/mL against porcine red blood cells.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18506 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18506.

Physicochemical Information

    • Formula

    • C109H190N32O24S2

    • Absent Amino Acids

    • DEHMNPQSWY

    • Common Amino Acids

    • K

    • Mass

    • 2397.03

    • PI

    • 10.59

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +7

    • Boman Index

    • -2768

    • Hydrophobicity

    • 0.105

    • Aliphatic Index

    • 88.1

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 6.25

    • Polar Residues

    • 6

DRAMP18506

DRAMP18506 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive, Gram-negative bacteria, and lower hemolytic activity than OG1.

Literature Information

  • ·Literature 1

    • Title

    • Effects of thioredoxin: SUMO and intein on soluble fusion expression of an antimicrobial peptide OG2 in Escherichia coli.

    • Reference

    • Protein Pept Lett. 2013 Jan;20(1):54-60.

    • Author

    • Xie YG, Luan C, Zhang HW, Han FF, Feng J, Choi YJ, Groleau D, Wang YZ.