• • DRAMP ID

  • DRAMP18707

• • Peptide Name

  • BACTENECIN 7 (bac 7, Pro-rich; bovine cathelicidin, cattle, ruminant, mammals, animals)

• • Source

  • Bos taurus (Bovine neutrophils)

• • Family

  • Belongs to the cathelicidin family.

• • Gene

  • CATHL3

• • Sequence

  • RRIRPRPPRLPRPRPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPL

• • Sequence Length

  • 60

• • UniProt Entry

  • P19661

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram-, Anti-Gram+

• • Target Organism

  • • [Ref.2777377] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12 µg/ml in Murller-Hinton, MIC=50 µg/ml in Iso-Sensitest), Salmonella typhimurium LT2 (MIC=12 µg/ml in Murller-Hinton, MIC=200 µg/ml in Iso-Sensitest), Salmonella typhimurium ATCC 14028 (MIC=25 µg/ml in Murller-Hinton, MIC=100 µg/ml in Iso-Sensitest), Klebsiella pneumoniae ATCC 13883 (MIC=12 µg/ml in Murller-Hinton, MIC=200 µg/ml in Iso-Sensitest), Enterobacter cloacae ATCC 13047 (MIC=25 µg/ml in Murller-Hinton, MIC=200 µg/ml in Iso-Sensitest), Pseudomonas aeruginosa ATCC 7700 (MIC=50 µg/ml in Murller-Hinton);
    • Gram-positive bacterium: Staphylococcus epidermidis ATCC 12228 (MIC=200 µg/ml in Murller-Hinton, MIC=200 µg/ml in Iso-Sensitest).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Rich

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • 4JWC resolved by NMR

• Predicted Structure

• There is no predicted structure for DRAMP18707.

DRAMP18707

• • Function

  • Antibacterial activity against an array of gram-negative and gram-positive bacteria.

• • PTM

  • Elastase is responsible for its maturation.

• ·Literature 1

• • Title

  • Purification, composition, and activity of two bactenecins, antibacterial peptides of bovine neutrophils.

• • Pubmed ID

  • 2777377

• • Reference

  • Infect Immun. 1989 Oct;57(10): 3142-6.

• • Author

  • Gennaro R, Skerlavaj B, Romeo D.