General Information

    • DRAMP ID

    • DRAMP18714

    • Peptide Name

    • Cathepsin G(1-5) (Human, primates, mammals, animals)

    • Source

    • Homo sapiens

    • Family

    • Belongs to the Cathepsin G N-terminal 1-5 truncted peptide.

    • Gene

    • Not found

    • Sequence

    • IIGGR

    • Sequence Length

    • 5

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18714 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18714.

Physicochemical Information

    • Formula

    • C22H42N8O6

    • Absent Amino Acids

    • ACDEFHKLMNPQSTVWY

    • Common Amino Acids

    • GI

    • Mass

    • 514.63

    • PI

    • 9.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +1

    • Boman Index

    • -320

    • Hydrophobicity

    • 0.74

    • Aliphatic Index

    • 156

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP18714

Comments Information

    • Function

    • Bactericidal activity against Gram-positive and Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Identification of the primary antimicrobial domains in human neutrophil cathepsin G.

    • Reference

    • J Biol Chem. 1990 Aug 15;265(23):13584-8.

    • Author

    • Bangalore N, Travis J, Onunka VC, Pohl J, Shafer WM.