• • DRAMP ID

  • DRAMP18716

• • Peptide Name

  • Histone H2B-1(HLP-1) (fish, animals)

• • Source

  • Ictalurus punctatus (Channel catfish) (Silurus punctatus)

• • Family

  • Belongs to the histone H2B family.

• • Gene

  • Not found

• • Sequence

  • PDPAKTAPKKGSKKAVTKA

• • Sequence Length

  • 19

• • UniProt Entry

  • P81903

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram-

• • Target Organism

  • • [Ref.9645227] Gram negative bacteria: Escherichia coli (MIC=0.37±0.023 μM).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • The nucleosome is a histone octamer

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP18716.

DRAMP18716

• • Function

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad-spectrum antimicrobial and antibacterial activity. It is important in the antimicrobial defenses of fish skin and possesses strong activity against saprolegnia, the most common fungal infection in fish. It is also inhibitory to fish bacterial pathogens, such as aeromonas hydrophila, vibrio alginolyticus and Escherichia coli D31.

• • PTM

  • Monoubiquitination at the C-terminal Lys gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. Phosphorylated during apoptosis; which facilitates apoptotic chromatin condensation.

• ·Literature 1

• • Title

  • Antimicrobial activity in the skin of the channel catfish Ictalurus punctatus: characterization of broad-spectrum histone-like antimicrobial proteins.

• • Pubmed ID

  • 9645227

• • Reference

  • Cell. Mol. Life Sci. 1998; 54:467-475

• • Author

  • Robinette D., Wada S., Arroll T., Levy MG., Miller WL., Noga EJ.