General Information
-
DRAMP ID
- DRAMP18718
-
Peptide Name
- SAAP fraction 2 (Surfactant-associated anionic peptides; Asp-rich; sheep, ruminant, mammals, animals)
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Source
- Ovis aries
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Family
- Not found
-
Gene
- Not found
-
Sequence
- GDDDDDD
-
Sequence Length
- 7
-
UniProt Entry
- No entry found
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
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Target Organism
-
- [Ref.8552650] Gram-negative bacterium: Pasteurella haemolytica (MBC50=0.04 mM in Zn-saline, MBC50=11.49 mM in Test buffer; Peptide/surfactant mixture MBC50=0.05 mM in Zn-saline, MBC50=6.44 mM in Test buffer; Peptide/serum mixture MBC50=0.05 mM in Zn-saline, MBC50=10.38 mM in Test buffer; Peptide/surfactant/serum mixture MBC50=0.06 mM in Zn-saline, MBC50=5.93 mM in Test buffer).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Rich
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18718.
Physicochemical Information
-
Formula
- C26H35N7O20
Absent Amino Acids
- ACEFHIKLMNPQRSTVW
Common Amino Acids
- D
Mass
- 765.6
PI
- 3.17
Basic Residues
- 0
Acidic Residues
- 6
Hydrophobic Residues
- 0
Net Charge
- -6
-
Boman Index
- -5138
Hydrophobicity
- -3.057
Aliphatic Index
- 0
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 1
DRAMP18718
Comments Information
Function
- Antibacterial activity against negative bacteria. No amidation at the C-terminus
Literature Information
- ·Literature 1
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Title
- Isolation of an ovine pulmonary surfactant-associated anionic peptide bactericidal for Pasteurella haemolytica.
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Pubmed ID
- 8552650
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Reference
- Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):412-6.
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Author
- Brogden KA, de Lucca AJ, Bland J, Elliott S.