• • DRAMP ID

  • DRAMP18719

• • Peptide Name

  • SAAP fraction 3 (Surfactant-associated anionic peptides; Asp-rich; sheep, ruminant, mammals, animals)

• • Source

  • Ovis aries

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • DDDDDDD

• • Sequence Length

  • 7

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.8552650] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MBC50=1.21 mM in Zn-saline), Streptococcus faecalis ATCC 29213 (MBC50=1.39 mM in Zn-saline);
    • Gram-negative bacteria: Escherichia coli ATCC 12795 (MBC50=0.64 mM in Zn-saline), Klebsiella pneumoniae ATCC 10031 (MBC50=0.62 mM in Zn-saline), Pasteurella haemolytica (MBC50=0.02 mM in Zn-saline, MBC50=8.52 mM in Test buffer; Peptide/surfactant mixture MBC50=0.01 mM in Zn-saline, MBC50=4.43 mM in Test buffer; Peptide/serum mixture MBC50=0.02 mM in Zn-saline, MBC50=4.95 mM in Test buffer; Peptide/surfactant/serum mixture MBC50=0.03 mM in Zn-saline, MBC50=2.79 mM in Test buffer).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Rich

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP18719.

DRAMP18719

• • Function

  • Antibacterial activity against Gram positive and negative bacteria. No amidation at the C-terminus

• ·Literature 1

• • Title

  • Isolation of an ovine pulmonary surfactant-associated anionic peptide bactericidal for Pasteurella haemolytica.

• • Pubmed ID

  • 8552650

• • Reference

  • Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):412-6.

• • Author

  • Brogden KA, de Lucca AJ, Bland J, Elliott S.