General Information
-
DRAMP ID
- DRAMP18723
-
Peptide Name
- CE (Cecropin A (1
-
Source
- Hyalophora cecropia (Cecropia moth)
-
Family
- Belongs to truncated Cecropin A.
-
Gene
- Not found
-
Sequence
- KWKLFKKI
-
Sequence Length
- 8
-
UniProt Entry
- P01507
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
-
Target Organism
-
- [Ref.28178190] Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=64 μM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- random coil
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18723.
Physicochemical Information
-
Formula
- C56H91N13O9
Absent Amino Acids
- ACDEGHMNPQRSTVY
Common Amino Acids
- K
Mass
- 1090.42
PI
- 10.48
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +4
-
Boman Index
- -705
Hydrophobicity
- -0.675
Aliphatic Index
- 97.5
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 785.71
Polar Residues
- 0
DRAMP18723
Comments Information
Function
- Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria.
Literature Information
- ·Literature 1
-
Title
- High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7
-
Pubmed ID
- 28178190
-
Reference
- Int J Mol Sci. 2017 Feb 6;18(2). pii: E339.
-
Author
- Tan T, Wu D, Li W, Zheng X, Li W, Shan A.