General Information
-
DRAMP ID
- DRAMP20790
-
Peptide Name
- Cecropin B (Insects, arthropods, invertebrates, animals)
-
Source
- Hyalophora cecropia (Cecropia moth)
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Family
- Belongs to the cecropin family.
-
Gene
- Not found
-
Sequence
- KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKALG
-
Sequence Length
- 36
-
UniProt Entry
- P01508
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.7019715] Gram-positive bacteria: Bacillus megaterium Bm11 (Inhibition zone=10.0 mm), Bacillus subtilis (Inhibition zone=7.2 mm);
- Gram-negative bacteria: Escherichia coli K12 D31 (Inhibition zone=12.5 mm), Serratia marcescens Db1108 (Inhibition zone=7.2 mm), Pseudomonas aeruginosa OT97 (Inhibition zone=9.7 mm), Xenorhabdus nematophilus Xn21 (Inhibition zone=10.0 mm).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation (Leu35) PMID:3857578
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20790.
Physicochemical Information
-
Formula
Absent Amino Acids
Common Amino Acids
Mass
- 3892.75
PI
- 10.73
Basic Residues
Acidic Residues
Hydrophobic Residues
Net Charge
-
Boman Index
- 0
Hydrophobicity
- 0
Aliphatic Index
- 0
Half Life
-
- Mammalian:
- Yeast:
- E.coli:
Extinction Coefficient Cystines
Absorbance 280nm
- 0
Polar Residues
DRAMP20790
Comments Information
Function
- Antibacterial activity against several Gram-positive and Gram-negative bacteria.
Literature Information
- ·Literature 1
-
Title
- Sequence and specificity of two antibacterial proteins involved in insect immunity
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Pubmed ID
- 7019715
-
Reference
- Nature. 1981 Jul 16;292(5820):246-8.
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Author
- Steiner H, Hultmark D, Engstr?m A, Bennich H, Boman HG.