General Information

    • DRAMP ID

    • DRAMP20791

    • Peptide Name

    • Cecropin A1 (insects, arthropods, invertebrates, animals)

    • Source

    • Aedes albopictus (Asian tiger mosquito)

    • Family

    • Not found

    • Gene

    • CECA1

    • Sequence

    • GGLKKLGKKLEGVGKRVFKASEKALPVAVGIKALGK

    • Sequence Length

    • 36

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20791 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20791.

Physicochemical Information

    • Formula

    • C169H300N48O42

    • Absent Amino Acids

    • CDHMNQTWY

    • Common Amino Acids

    • K

    • Mass

    • 3676.54

    • PI

    • 10.54

    • Basic Residues

    • 10

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +8

    • Boman Index

    • -1941

    • Hydrophobicity

    • -0.042

    • Aliphatic Index

    • 108.33

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 8

DRAMP20791

DRAMP20791 chydropathy plot

Comments Information

    • Function

    • Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Peptide sequence of an antibiotic cecropin from the vector mosquito, Aedes albopictus.

    • Reference

    • Biochem. Biophys. Res. Commun. 1998 Aug; 249(2):410-415.

    • Author

    • Sun D, Eccleston ER, Fallon AM.