General Information

    • DRAMP ID

    • DRAMP20792

    • Peptide Name

    • Maculatin 1.1 (Frog, amphibians, animals)

    • Source

    • Litoria genimaculata (Green-eyed tree frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLFVGVLAKVAAHVVPAIAEHF

    • Sequence Length

    • 22

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.9620615] Gram positive bacteria: Bacillus cereus (MIC=50 μg/ml), Leuconostoc lactis (MIC=25 μg/ml), Listeria innocua (MIC=100 μg/ml), Micrococcus luteus (MIC=12.5 μg/ml), Staphylococcus aureus (MIC=6-12.5 μg/ml), Staphylococcus epidermidis (MIC=12.5 μg/ml), Streptococcus faecalis (MIC=25 μg/ml), Streptococcus uberis (MIC=3 μg/ml);
      • Gram-negative bacteria: Escherichia coli (MIC=100 μg/ml), Pasteurella multocida (MIC=100 μg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20792 helical wheel diagram

    • PDB ID

    • 2MMJ resolved by NMR

    • Predicted Structure

    • There is no predicted structure for DRAMP20792.

Physicochemical Information

    • Formula

    • C108H169N27O25

    • Absent Amino Acids

    • CDMNQRSTWY

    • Common Amino Acids

    • AV

    • Mass

    • 2245.7

    • PI

    • 6.92

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +2

    • Boman Index

    • 3017

    • Hydrophobicity

    • 1.432

    • Aliphatic Index

    • 141.82

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP20792

DRAMP20792 chydropathy plot

Comments Information

    • Function

    • Maculatin-1.1 shows significant antibacterial activity against Gram-positive bacteria, less against Gram-negative bacteria. Maculatin-1.1.1 is inactive.

    • Tissue specificity

    • Expressed by the skin dorsal glands.

Literature Information

  • ·Literature 1

    • Title

    • The maculatin peptide from the skin glands of the tree frog Litoria genimaculata: a comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1

    • Reference

    • J. Pept. Sci. 1998 Apr; 4(2): 111-115.

    • Author

    • Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.