General Information
-
DRAMP ID
- DRAMP20794
-
Peptide Name
- Turkey Heterophil Peptide 2 (THP-2; avian beta-defensin, birds, animals)
-
Source
- Meleagris gallopavo (Wild turkey)
-
Family
- Belongs to the beta-defensin family.
-
Gene
- Not found
-
Sequence
- LFCKRGTCHFGRCPSHLIKV
-
Sequence Length
- 20
-
UniProt Entry
- P80392
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Bridge
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20794.
Physicochemical Information
-
Formula
Absent Amino Acids
Common Amino Acids
Mass
- 2302.8
PI
- 9.62
Basic Residues
Acidic Residues
Hydrophobic Residues
Net Charge
-
Boman Index
- 0
Hydrophobicity
- 0
Aliphatic Index
- 0
Half Life
-
- Mammalian:
- Yeast:
- E.coli:
Extinction Coefficient Cystines
Absorbance 280nm
- 0
Polar Residues
DRAMP20794
Comments Information
Function
- Antibacterial activity against the Gram-positive bacterium Staphylococcus aureus. Lacks antibacterial activity against the Gram-negative bacterium Escherichia coli K-12.
Tissue specificity
- Expressed in circulating heterophil granulocytes and bone marrow (at protein level).
Literature Information
- ·Literature 1
-
Title
- Isolation of antimicrobial peptides from avian heterophils.
-
Pubmed ID
- 7964174
-
Reference
- J. Leukoc. Biol. 1994 Nov; 56: 661-665.
-
Author
- Evans EW, Beach GG, Wunderlich J, Harmon BG.