General Information

    • DRAMP ID

    • DRAMP20796

    • Peptide Name

    • So-D6 (S. oleracea defensin 6, spinach defensins; plants)

    • Source

    • Spinacia oleracea (Spinach)

    • Family

    • Belongs to the DEFL family. Group II subfamily.

    • Gene

    • Not found

    • Sequence

    • GIFSNMYXRTPAGYFRGPXGYXXN

    • Sequence Length

    • 24

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

      • [Ref.9762899] Gram-positive bacterium: Clavibacter michiganensis (EC50=1 μM);
      • Gram-negative bacterium: Ralstonia solanacearum (EC50=6 μM);
      • Fusarium solani (EC50=11 μM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20796 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20796.

Physicochemical Information

    • Formula

    • Absent Amino Acids

    • Common Amino Acids

    • Mass

    • 2713.86

    • PI

    • 9.7

    • Basic Residues

    • Acidic Residues

    • Hydrophobic Residues

    • Net Charge

    • Boman Index

    • 0

    • Hydrophobicity

    • 0

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:
      • Yeast:
      • E.coli:

    • Extinction Coefficient Cystines

    • Absorbance 280nm

    • 0

    • Polar Residues

DRAMP20796

DRAMP20796 chydropathy plot

Comments Information

    • Function

    • Antimicrobial activity against Fungi, Gram-positive and Gram-negative bacteria.

    • Tissue specificity

    • Distributed in the epidermal cell layer of leaves and in the subepidermal layer region of stems. Not in roots.

    • Developmental stage

    • Present throughout the life of the leaf.

Literature Information

  • ·Literature 1

    • Title

    • Novel defensin subfamily from spinach (Spinacia oleracea).

    • Reference

    • FEBS Lett. 1998 Sep 18;435(2-3): 159-162.

    • Author

    • Segura A, Moreno M, Molina A, Garcia-Olmedo F