General Information

    • DRAMP ID

    • DRAMP20802

    • Peptide Name

    • CPF-AM1 (caerulein precursor fragment-AM1, frogs, amphibians, animals)

    • Source

    • Xenopus amieti (skin secretions, Africa)

    • Family

    • Belongs to the CPF family.

    • Gene

    • Not found

    • Sequence

    • GLGSVLGKALKIGANLL

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.20226221] Gram-positive bacteria: Staphylococcus aureus (MIC>200μM) ;
      • Gram-negative bacteria: Escherichia coli (MIC>200μM).

    • Hemolytic Activity

      • [Ref.20226221] LC50>200μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membranes

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20802 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20802.

Physicochemical Information

    • Formula

    • C74H134N20O20

    • Absent Amino Acids

    • CDEFHMPQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 1624

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +2

    • Boman Index

    • 1980

    • Hydrophobicity

    • 1.035

    • Aliphatic Index

    • 166.47

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP20802

Comments Information

    • Function

    • Antibacterial activity against the Gram-positive and Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Orthologs of magainin, PGLa, procaerulein-derived, and proxenopsin-derived peptides from skin secretions of the octoploid frog Xenopus amieti (Pipidae).

    • Reference

    • Peptides. 2010 Jun;31(6):989-94.

    • Author

    • Conlon JM, Al-Ghaferi N, Ahmed E, Meetani MA, Leprince J, Nielsen PF.