General Information

    • DRAMP ID

    • DRAMP20803

    • Peptide Name

    • moronecidin-like peptide

    • Source

    • Hippocampus comes

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FFRNLWKGAKAAFRAGHAAWRA

    • Sequence Length

    • 22

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.30039186] Gram-positive bacteria:Staphylococcus aureus ATCC 25923 (MIC=3.12 μg/ml),Staphylococcus epidermidis ATCC 1435 (MIC=1.56 μg/ml),Staphylococcus aureus MRSA (MIC=3.12 μg/ml);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.25 μg/ml), Pseudomonas aeruginosa ATCC10662 (MIC=50 μg/ml),Acinetobacter baumannii clinical isolate (MIC=6.25 μg/ml);
      • Fungi:Candida albicans clinical isolate (MIC=6.25 μg/ml), Candida tropicalis clinical isolate (MIC=6.25 μg/ml)

    • Hemolytic Activity

      • [Ref.30039186] 50% hemolysis at 87.5μg/ml,25% hemolysis at 50μg/ml,60% hemolysis at 100μg/ml against human red cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • The peptide is Schiffer

    • Helical Wheel Diagram

    • DRAMP20803 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20803.

Physicochemical Information

    • Formula

    • C120H174N38O24

    • Absent Amino Acids

    • CDEIMPQSTVY

    • Common Amino Acids

    • A

    • Mass

    • 2532.94

    • PI

    • 12.31

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +6

    • Boman Index

    • -3409

    • Hydrophobicity

    • -0.264

    • Aliphatic Index

    • 49.55

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 523.81

    • Polar Residues

    • 3

DRAMP20803

DRAMP20803 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against the Gram-positive and Gram-negative bacteria; antifungal activity.

Literature Information

  • ·Literature 1

    • Title

    • Identification and Characterization of Novel Antimicrobial Peptide from Hippocampus comes by In Silico and Experimental Studies

    • Reference

    • Mar Biotechnol (NY). 2018 Dec;20(6):718-728.

    • Author

    • Mohammadi M, Taheri B, Momenzadeh N, Salarinia R, Nabipour I, Farshadzadeh Z, Bargahi A.