General Information

    • DRAMP ID

    • DRAMP20804

    • Peptide Name

    • AI-hemocidins 2 (Hb-1 truncated peptide)

    • Source

    • Arca inflata

    • Family

    • Belongs to truncated Hb-1

    • Gene

    • Not found

    • Sequence

    • DLRDSWKVIGSDKK

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.28661457] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=45.54 μM), Pseudomonas aeruginosa ATCC 27853 (MIC=91.08 μM), Pseudomonas aeruginosa clinical isolate (MIC=91.08 μM);
      • Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=22.77 μM), Bacillus subtilis ATCC 6633 (MIC=182.16 μM).

    • Hemolytic Activity

      • [Ref.28661457] 10.27 ± 0.42% hemolysis at 500 μg/mL against murine red blood cells.

    • Cytotoxicity

      • [Ref.28661457] The cell viability of HEK293 at the peptide concentration of 250 μg/ml is 88.18±9.48%. IC50 > 1000 μg/ml against HEK293 cells.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix,random coil

    • Structure Description

    • Peptides displayed random coil conformations in PBS, the spectra of AI-hemocidin 2 featured an

    • Helical Wheel Diagram

    • DRAMP20804 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20804.

Physicochemical Information

    • Formula

    • C72H119N21O23

    • Absent Amino Acids

    • ACEFHMNPQTY

    • Common Amino Acids

    • DK

    • Mass

    • 1646.86

    • PI

    • 8.5

    • Basic Residues

    • 4

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +1

    • Boman Index

    • -4738

    • Hydrophobicity

    • -1.221

    • Aliphatic Index

    • 76.43

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 423.08

    • Polar Residues

    • 3

DRAMP20804

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative and Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Antibacterial Activity of AI-Hemocidin 2, a Novel N-Terminal Peptide of Hemoglobin Purified from Arca inflata

    • Reference

    • Mar Drugs. 2017 Jun 29;15(7).

    • Author

    • Li C, Zhu J, Wang Y, Chen Y, Song L, Zheng W, Li J, Yu R.