General Information
-
DRAMP ID
- DRAMP20804
-
Peptide Name
- AI-hemocidins 2 (Hb-1 truncated peptide)
-
Source
- Arca inflata
-
Family
- Belongs to truncated Hb-1
-
Gene
- Not found
-
Sequence
- DLRDSWKVIGSDKK
-
Sequence Length
- 14
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.28661457] Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=45.54 μM), Pseudomonas aeruginosa ATCC 27853 (MIC=91.08 μM), Pseudomonas aeruginosa clinical isolate (MIC=91.08 μM);
- Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=22.77 μM), Bacillus subtilis ATCC 6633 (MIC=182.16 μM).
-
Hemolytic Activity
-
- [Ref.28661457] 10.27 ± 0.42% hemolysis at 500 μg/mL against murine red blood cells.
-
Cytotoxicity
-
- [Ref.28661457] The cell viability of HEK293 at the peptide concentration of 250 μg/ml is 88.18±9.48%. IC50 > 1000 μg/ml against HEK293 cells.
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Alpha helix,random coil
-
Structure Description
- Peptides displayed random coil conformations in PBS, the spectra of AI-hemocidin 2 featured an
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20804.
Physicochemical Information
-
Formula
- C72H119N21O23
Absent Amino Acids
- ACEFHMNPQTY
Common Amino Acids
- DK
Mass
- 1646.86
PI
- 8.5
Basic Residues
- 4
Acidic Residues
- 3
Hydrophobic Residues
- 4
Net Charge
- +1
-
Boman Index
- -4738
Hydrophobicity
- -1.221
Aliphatic Index
- 76.43
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 423.08
Polar Residues
- 3
DRAMP20804
Comments Information
Function
- Antibacterial activity against the Gram-negative and Gram-positive bacteria.
Literature Information
- ·Literature 1
-
Title
- Antibacterial Activity of AI-Hemocidin 2, a Novel N-Terminal Peptide of Hemoglobin Purified from Arca inflata
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Pubmed ID
- 28661457
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Reference
- Mar Drugs. 2017 Jun 29;15(7).
-
Author
- Li C, Zhu J, Wang Y, Chen Y, Song L, Zheng W, Li J, Yu R.