General Information

    • DRAMP ID

    • DRAMP20806

    • Peptide Name

    • Apo6 APOC167-88

    • Source

    • American alligator

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KTRNWFSEHFKKVKEKLKDTFA

    • Sequence Length

    • 22

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.27542832] Gram-positive bacteria:Staphylococcus aureus ATCC BAA-1718 (EC50=2.31μg/ml), Staphylococcus aureus ATCC 33592 (EC50=0.883μg/ml);
      • Gram-negative bacteria:Escherichia coli ATCC 4157 (EC50=3.85μg/ml), Escherichia coli ATCC 51659 (EC50=9.07μg/ml), Pseudomonas aeruginosa PAO1 (EC50=1.17μg/ml), Pseudomonas aeruginosa ATCC BAA-2110 (EC50=0.130μg/ml), Acinetobacter baumannii ATCC 9955 (EC50=0.233μg/ml), Acinetobacter baumannii ATCC BAA-1794 (EC50=0.126μg/ml)

    • Hemolytic Activity

      • [Ref.27542832] Not hemolytic to sheep red blood cells.

    • Cytotoxicity

      • [Ref.27542832] The cell proliferation of A549 human lung epithelial cells is 190%, 167%, 150%, 135% and 144% at peptide concentrations of 1 μg/ml, 10 μg/ml, 25 μg/ml, 50 μg/ml, 100 μg/ml

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix,beta-sheet,beta-turn,random coil

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20806 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20806.

Physicochemical Information

    • Formula

    • C129H199N35O33

    • Absent Amino Acids

    • CGIMPQY

    • Common Amino Acids

    • K

    • Mass

    • 2768.21

    • PI

    • 10

    • Basic Residues

    • 8

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +5

    • Boman Index

    • -6836

    • Hydrophobicity

    • -1.364

    • Aliphatic Index

    • 35.45

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 261.9

    • Polar Residues

    • 4

DRAMP20806

DRAMP20806 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative and Gram-positive bacteria

Literature Information

  • ·Literature 1

    • Title

    • Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii

    • Reference

    • BMC Microbiol. 2016 Aug 19;16(1):189.

    • Author

    • Barksdale SM, Hrifko EJ, Chung EM, van Hoek ML.