• • DRAMP ID

  • DRAMP20809

• • Peptide Name

  • RI18 (PMAP-36 peptide derivative)

• • Source

  • Synthetic construct

• • Family

  • Derived from PMAP-36

• • Gene

  • Not found

• • Sequence

  • RKKTRKRLKKIGKVLKWI

• • Sequence Length

  • 18

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.27251456] Gram-positive bacteria: Staphylococcus aureus 29213 (MIC=4 μM, MBC=4 μM), Staphylococcus aureus 25923 (MIC=8 μM, MBC=8 μM), Staphylococcus epidermidis 12228 (MIC=4 μM, MBC=16 μM), Bacillus subtilis 63501 (MIC=1 μM, MBC=2 μM);
    • Gram-negative bacteria: Escherichia coli 25922 (MIC=2 μM, MBC=4 μM), Escherichia coli EC183 (MIC=1 μM, MBC=2 μM), Escherichia coli 1005 (MIC=2 μM, MBC=4 μM), Salmonella typhimurium C77-31 (MIC=2 μM, MBC=4 μM);
    • Fungi: Candida albicans 2.2086 (MIC=16 μM, MFC=32 μM), Candida albicans CA276 (MIC=8 μM, MFC=16 μM), Candida tropicalis 2.1975 (MIC=2 μM, MFC=4 μM), Candida krusei 2.1857 (MIC=4 μM, MFC=8 μM).

• • Hemolytic Activity

  • • [Ref.27251456] 5% hemolysis at 128 μM, MHC=128 μM against human red blood cells.

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Alpha helix

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP20809.

DRAMP20809

• • Function

  • Antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria and Fungi..

• ·Literature 1

• • Title

  • Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida.

• • Pubmed ID

  • 27251456

• • Reference

  • Sci Rep. 2016 Jun 2;6:27258.

• • Author

  • Lyu Y, Yang Y, Lyu X, Dong N, Shan A.