General Information
-
DRAMP ID
- DRAMP20814
-
Peptide Name
- S1K8
-
Source
- Synthetic construct
-
Family
- Belongs to the Hp1404 family
-
Gene
- Not found
-
Sequence
- SILGKLWKGVKSIF
-
Sequence Length
- 14
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.26952110] Gram-positive bacteria:Staphylococcus aureus AB94004 (MIC=6.25μg/mL), Staphylococcus aureus ATCC6538 (MIC=6.25μg/mL), Staphylococcus aureus ATCC25923 (MIC=6.25μg/mL), Staphylococcus aureus MRSA P1381 (MIC=12.5μg/mL), Staphylococcus aureus MRSA P1374 (MIC=6.25μg/mL);
- Gram-negative bacteria: Escherichia coli AB94012 (MIC=25μg/mL), Escherichia coli ATCC25922 (MIC=50μg/mL), Pseudomonas aeruginosa AB93066 (MIC=50μg/mL), Pseudomonas aeruginosa ATCC9027 (MIC=25μg/mL)
-
Hemolytic Activity
-
- [Ref.26952110] 15% hemolysis at 200μg/mL, 45% hemolysis at 400μg/mL against human red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Alpha helix
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20814.
Physicochemical Information
-
Formula
- C77H126N18O17
Absent Amino Acids
- ACDEHMNPQRTY
Common Amino Acids
- K
Mass
- 1575.96
PI
- 10.3
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 7
Net Charge
- +3
-
Boman Index
- 746
Hydrophobicity
- 0.614
Aliphatic Index
- 132.14
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 423.08
Polar Residues
- 4
DRAMP20814
Comments Information
Function
- Antibacterial activity against the Gram-negative and Gram-positive bacteria
Literature Information
- ·Literature 1
-
Title
- K1K8: an Hp1404-derived antibacterial peptide
-
Pubmed ID
- 26952110
-
Reference
- Appl Microbiol Biotechnol. 2016 Jun;100(11):5069-77.
-
Author
- Li Z, Liu G, Meng L, Yu W, Xu X, Li W, Wu Y, Cao Z.