• • DRAMP ID

  • DRAMP20815

• • Peptide Name

  • F1K8

• • Source

  • Synthetic construct

• • Family

  • Belongs to the Hp1404 family

• • Gene

  • Not found

• • Sequence

  • FILGKLWKGVKSIF

• • Sequence Length

  • 14

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.26952110] Gram-positive bacteria:Staphylococcus aureus AB94004 (MIC=6.25μg/mL), Staphylococcus aureus ATCC6538 (MIC=6.25μg/mL), Staphylococcus aureus ATCC25923 (MIC=6.25μg/mL), Staphylococcus aureus MRSA P1381 (MIC=12.5μg/mL), Staphylococcus aureus MRSA P1374 (MIC=12.5μg/mL);
    • Gram-negative bacteria: Escherichia coli AB94012 (MIC=25μg/mL), Escherichia coli ATCC25922 (MIC=50μg/mL), Pseudomonas aeruginosa AB93066 (MIC=50μg/mL), Pseudomonas aeruginosa ATCC9027 (MIC=50μg/mL)

• • Hemolytic Activity

  • • [Ref.26952110] 2% hemolysis at 100μg/mL, 35% hemolysis at 200μg/mL, 70% hemolysis at 400μg/mL against human red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Alpha helix

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP20815.

DRAMP20815

• • Function

  • Antibacterial activity against the Gram-negative and Gram-positive bacteria

• ·Literature 1

• • Title

  • K1K8: an Hp1404-derived antibacterial peptide

• • Pubmed ID

  • 26952110

• • Reference

  • Appl Microbiol Biotechnol. 2016 Jun;100(11):5069-77.

• • Author

  • Li Z, Liu G, Meng L, Yu W, Xu X, Li W, Wu Y, Cao Z.